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Bio-Rad Labs., Inc. v. 10X Genomics, Inc.

Citation: 322 F. Supp. 3d 537Docket: Civil Action No. 1:15-cv-00152-RGA

Court: District Court, D. Delaware; June 26, 2018; Federal District Court

Narrative Opinion Summary

In a complex patent litigation case, the court addressed several motions for summary judgment regarding alleged non-infringement and invalidity of multiple patents. The Defendant sought summary judgment for non-infringement of the '083 patent, arguing that the inclusion of fluorine in their products did not violate the patent's 'non-fluorinated microchannel' requirement. The court found a genuine dispute of material fact regarding whether such inclusion constituted a contaminant. Additionally, the court examined the application of the doctrine of equivalents, concluding that the Plaintiffs had successfully rebutted the presumption of prosecution history estoppel by demonstrating a tangential relationship between the narrowing amendment and the alleged equivalent. Regarding the '148 patent, the court granted summary judgment for the GemCode Long Read product but denied it for the Chromium Genome/Exome product due to unresolved issues of equivalence in the DNA denaturation process. The Defendant's arguments for non-infringement of the '091 patent were also rejected, as the court interpreted the claim language to not require each plug to contain both plug-fluids. Lastly, the court denied the Defendant's motion for invalidity of the '407 patent due to factual disputes over anticipation by prior art. Consequently, the court's order partially granted and partially denied both parties' motions, reflecting the nuanced and contested nature of patent claim interpretation and application in this case.

Legal Issues Addressed

Claim Construction and Literal Infringement

Application: The court supports Plaintiffs' interpretation that physical contact is not required by the patent claims, denying Defendant's motion for non-infringement.

Reasoning: Plaintiffs counter that the patent claims do not require physical contact, only that the fluorinated surfactant creates a higher surface tension at the plug-fluid/microchannel wall interface than at the plug-fluid/carrier fluid interface.

Doctrine of Equivalents and Prosecution History Estoppel

Application: The court examines whether the amendment to add 'non-fluorinated' was related to avoiding prior art and concludes it had a tangential relationship, allowing the doctrine of equivalents to apply.

Reasoning: In this case, the presumption of total surrender applies since the patentee added 'non-flourinated' before 'microchannel' to overcome a rejection based on prior art. However, it is determined that the plaintiffs have successfully rebutted the presumption by showing that the rationale for the narrowing amendment had a tangential relationship to the alleged equivalent.

Invalidity of Patent Claims

Application: Defendant's motion for invalidity of the '407 patent is denied due to material fact disputes regarding anticipation by prior art.

Reasoning: For the '407 patent, Defendant seeks summary judgment of invalidity based on the Quake reference, claiming it discloses all steps of claim 1. Despite Defendant's reliance on a specific paragraph from Quake, the court finds material facts in dispute concerning anticipation of claim 1.

Non-Infringement of Patent Claims

Application: Defendant argues non-infringement due to the presence of fluorine in its microfluidic chips, which contradicts the requirement for a 'non-fluorinated microchannel'.

Reasoning: Regarding the '083 patent, Defendant asserts it does not literally infringe due to the presence of fluorine in its microfluidic chips, which contradicts the patent's requirement for a 'non-fluorinated microchannel.'

Specific Exclusion in Patent Claims

Application: Defendant argues that the specific exclusion principle prevents Plaintiffs from claiming infringement on a product with a 'fluorinated microchannel'.

Reasoning: Defendant contends that even if prosecution history is irrelevant, Plaintiffs are barred from claiming infringement under the doctrine of equivalents due to the principle of 'specific exclusion.'

Summary Judgment on Patent Non-Infringement

Application: Defendant's motion concerning the '148 patent is granted for one product but denied for another due to factual disputes about equivalence of certain processes.

Reasoning: Regarding the '148 patent, Defendant seeks summary judgment of non-infringement for its GemCode Long Read product, which Plaintiffs do not dispute under the Court's interpretation of 'target sequence.'