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Abraxis Bioscience v. Mayne Pharma

Citations: 467 F.3d 1370; 80 U.S.P.Q. 2d (BNA) 1705; 2006 U.S. App. LEXIS 28199; 2006 WL 3302663Docket: 2006-1118

Court: Court of Appeals for the Federal Circuit; November 14, 2006; Federal Appellate Court

Original Court Document: View Document

Narrative Opinion Summary

This case involves a patent infringement dispute between Mayne Pharma (USA) Inc. and AstraZeneca Pharmaceuticals LP concerning several patents related to an injectable emulsion used as an anesthetic. The United States District Court for the Southern District of New York initially found Mayne in literal infringement and under the doctrine of equivalents of AstraZeneca's patents, which cover a formulation incorporating disodium edetate as a preservative. On appeal, the Federal Circuit reversed the district court's finding of literal infringement due to an incorrect interpretation of the term 'edetate' but upheld the decision under the doctrine of equivalents. The court determined that although Mayne's use of calcium trisodium DTPA in its generic propofol formulation did not literally infringe the patent claims, it was equivalent under the function-way-result test. The appellate court concluded that the district court's broader definition of 'edetate' was inappropriate, limiting it to EDTA salts or derivatives. However, it affirmed the finding of equivalence, as the differences between the claimed and accused products were deemed insubstantial, maintaining the district court's judgment against Mayne under the doctrine of equivalents.

Legal Issues Addressed

Claim Scope and Equivalents

Application: The court finds that Mayne's argument against the equivalence of calcium trisodium DTPA fails because there was no clear disavowal of other polyaminocarboxylates as equivalents.

Reasoning: In contrast, the court found that Mayne did not clearly disavow other polyaminocarboxylates, such as calcium trisodium DTPA, when claiming edetate.

Doctrine of Equivalents

Application: The court upholds the finding of infringement under the doctrine of equivalents, determining that the accused product performs similarly despite not being a literal match.

Reasoning: The appellate court upheld the judgment of infringement under the doctrine of equivalents.

Function-Way-Result Test

Application: The district court's application of the function-way-result test supports the equivalence between the patented and accused products through similar chelation activities.

Reasoning: The court conducted a function-way-result analysis, identifying edetate's function as inhibiting microbial growth in oil-in-water emulsions through metal ion chelation.

Literal Infringement

Application: The appellate court reverses the district court's finding of literal infringement due to an erroneous interpretation of the term 'edetate', which in the accused product is not present.

Reasoning: This admission led the court to conclude that the district court erred in finding literal infringement, as neither EDTA nor its derivatives exist in the accused formulation.

Patent Claim Construction

Application: The appellate court reviews the district court's construction of the term 'edetate', determining that the lower court's definition was overly broad.

Reasoning: The appellate court identified an error in the district court's construction of the term 'edetate,' leading to a reversal of the finding of literal infringement.